Indoor air pollution poses a significant threat to global health, contributing to respiratory and cardiovascular diseases and exacerbating environmental challenges. Addressing this critical issue, this study evaluates the performance of a novel air purification device, the MopFan – a system integrating advanced filtration technologies, including high-efficiency particulate air filters, photocatalytic oxidation, and bio-aerogel materials, principally designed to mitigate gaseous pollutants. The MopFan was tested under controlled environmental conditions across three room sizes and varying ventilation states to assess its efficacy in removing volatile organic compounds (VOCs) and formaldehyde (HCHO), common indoor air pollutants. Employing ethanol vapour as pollutant, the results demonstrated reductions in gaseous pollutant concentrations – specifically, VOCs and HCHO – of up to 65% in small, enclosed spaces, with performance influenced by room size and ventilation. The device’s multi-stage filtration system effectively decomposed pollutants, leveraging TiO₂-coated fibres activated by ultraviolet C light and bio-aerogel filters for enhanced antiviral and chemical filtration. Particularly, ventilation plays a critical role in pollutant dispersion. Further comparative analysis is recommended to ascertain whether such a reduction suffices to meet the current regulatory guidelines. This study highlights the MopFan’s potential as a sustainable, scalable solution for improving indoor air quality (IAQ) in diverse settings. The MopFan’s innovative design, combining eco-friendly materials and advanced filtration methods, offers a pathway to mitigate indoor air pollution’s health impacts, aligning with global sustainability and public health objectives. This research advances the scientific understanding of IAQ interventions and supports the development of effective, scalable solutions.