The numerous researches of the Maisotsenko cycle (M-cycle) application for air-conditioning purposes prove 3 to 10 times (depending on air humidity) energy saving compared to the conventional vapour-compression systems. Another important value of air-conditioning through the M-cycle is the air displacement process that serves to supply fresh air into the conditioned premises continuously at the fixed energy input. Being considered as a pure heat recuperative process, the M-cycle cooling requires water makeup that is obviously high in the dry climate zones. Conversely, in the humid zones, where absolute humidity exceeds 11g/kg of the dry air, the M-cycle based air-conditioners are unable to meet the air dehumidification challenge and require the conventional or state-of-the art technologies to remove the excess moisture from the processed air before its substantial cooling to the set temperatures. In order to validate the performance of the M-cycle based air-conditioners in the humid zones and minimize the overall energy input for cooling and dehumidification processes, a comparative analysis of the latest desiccant dehumidifiers and ejector cooling systems was performed. The study is devoted to disclose the pros and cons of the existed schemes of the M-cycle based cooling systems for the habitant and technological conditions. Alternatively, it was proposed the hybrid M-cycle/desiccant/ejector air-conditioner that may serve to be one of the most energy efficient cooling system for the humid climate conditions, where 85% of the world's air-cooling demand is located.