In a quest to reduce the energy consumption in buildings there has been and introduction of different alternative conditioning systems, namely a Radiant Ceiling System and an Active Beam system which can be used to condition spaces. This paper will attempt to identify any energy and cost savings of these different systems, as well as occupant comfort conditions. As base case, we have used a traditional overhead Variable Air Volume system, a traditional Fan Coils system has also been included in this comparison. The building used for the simulation comparison is 200,000 ft2, 8 story building situated in both New York and Los Angeles. The base case model and the three alternatives have all been constructed in the simulation model in accordance with ASHRAE 90.1 -2013.