Heating, Ventilation and Air-Conditioning (HVAC) systems equipped with Air-Handling Units (AHUs) significantly contribute to the overall energy demand of the building sector and they frequently operate under faulty conditions due to lack of proper maintenance, component failure or incorrect installation. Automated Fault Detection and Diagnosis (AFDD) allows faults to be automatically recognised as well as causes identified and/or location of faults. In comparison to traditional maintenance programs, it can offer several interrelated benefits, including energy savings, operating cost reduction, lower greenhouse gas emissions and improved comfort. In particular, data-driven AFDD tools are easier to utilize and could achieve higher accuracy with respect to other AFDD approaches, but they rely on operational data collected from AHUs operating under both normal and faulty conditions. However, performing experiments to derive such data is challenging, time-consuming, expensive, and covers a limited range of operating conditions. An effective alternative is represented by the exploitation of AHU simulation models which facilitate the generation of broad faulty operational datasets while exploring different AHU configurations, sizes, control logics and wide weather loads scenarios. In this paper the most significant scientific papers focusing on the development of digital twins of AHUs aiming at the development of data-driven AFDD algorithms were systematically reviewed and categorized in terms of AHU operating schemes, software environments, faults type and severity, simulation time-step, range of climatic conditions. This review was performed in order to highlight the current research gaps and guide the future development of new and accurate AHU simulation models to perform fault impact scenario analyses as well as support the deployment of data-driven AFDD methods. The analysis highlighted that: (i) dual-duct dual-fan air variable volume AHUs have been poorly modelled and simulated; (ii) the most used software platform for modelling and simulating AHUs’ operation was EnergyPlus; (iii) faults related to the humidifier have not been studied sufficiently; (iv) the effects associated with the simultaneous occurrence of multiple faults have been assessed in few cases; (v) performance analyses of AHUs under shoulder seasons and Mediterranean climatic conditions require further research.