Poor glazing insulation and natural window ventilation represent an average of 15% and 35% primary energy consumption in most of residential and commercial buildings, which is crucial in energy conservation for net zero energy target in 2050. Besides, occupants spend about 90% of their time on indoor activities, where sick building syndromes (e.g., pruritus, dry cough, ocular pruritus, and headache) are attributed to poor indoor air quality, as well as diseases like extrinsic allergic alveolitis and asthma. This paper proposed a smart all-in-one window by integrating the PV vacuum glazing, heat pipe-based window heat recovery ventilation unit and battery storage for space heating, cooling, insulation, ventilation, heat recovery and renewable electricity generation and storage. The PV vacuum glazing generate the electricity and stored in the battery to supply the window heat recovery ventilation when required. And the glazing insulation achieves U-value of 0.5 W/m2K with glazing solar to electricity conversion efficiency of 5.28% with light transparency of 50%. In addition, the window heat recovery unit using the heat pipe as high thermal conducting method with heat recovery efficiency between 74%-94% with variation of ventilation rate between 10-60m3/h. A 1940s’ British masonry house is selected as a case study to evaluate the comprehensive energy, comfort, and economic performance by utilizing the all-in-one smart window. Results indicate that the room total energy is reduced by 15.3% annually with quick payback periods of 7 years. Moreover, grid electricity consumption for lighting and ventilation reduced by 84.6%. It is also noted that the average indoor CO2 content during sleep time is reduced from 1740PPM to 950PPM as 100% warm and fresh air inlet from the window heat recovery unit, which indicates a significant improvement of indoor thermal comfort. Thus, the proposed smart all-in-one window could play a significant role in the future lo-carbon building design in both retrofit and newly constructed building.